Monogenic inheritance Quiz

Monogenic inheritance quiz covers the basic knowledge and concept regarding monogenic inheritance. In addition, monogenic inheritance, also known as single-gene or Mendelian inheritance, is a fundamental concept in genetics where a trait is determined by a single gene. Thus single gene can exist in different forms, known as alleles, which are variations of the DNA sequence at a specific locus on a chromosome. These alleles pass from parents to offspring follows the principles established by Gregor Mendel in the 19th century, hence the term Mendelian inheritance. Inheritance pattern of monogenic trait includes, autosomal (both dominant and recessive) and X-linked (dominant and recessive). Furthermore, monogenic diseases are a key application of this concept, where mutations in a single gene trigger disorders . Such as, Cystic fibrosis, Huntington’s disease and sickle cell anemia are well-known examples of monogenic inheritance. 

The aim of this quiz to assess our audience understanding of this important topic of fundamentals of genetics.

Our Previous Fundamentals of Genetics Quiz

The following quizzes will help you to ASSES your understanding of Fundamentals of Genetics concepts.

1. Fundamentals of Genetics Quiz 1
2. Fundamentals of Genetics Quiz 2
3. Mendel’s Law of Dominance Quiz
4. Mendel’s Law of Segregation Quiz
5. Mendel’s Law of Independent Assortment Quiz

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Monogenic Inheritance Quiz is also available on youtube click here to watch. Click the following links to watch our other quizzes of Fundamentals of Genetics

• Fundamentals of Genetics Quiz 1
• Fundamentals of Genetics Quiz 2
• Mendel’s Law of Dominance Quiz
• Mendel’s Law of Segregation Quiz
• Mendel’s Law of Independent Assortment Quiz

Questions of Monogenic Inheritance Quiz

This quiz consists of the following questions. For detail study or more information of these questions, consult the given references.

• Monogenic Inheritance can be distinguished into¹
• When affected individual present in one or more successive generations is known as²
• When affected individual has unaffected parents³.
• Both male & female can be affected in a ratio of 1:1 (details in ref. 2)
• Vertical pattern of inheritance indicates⁴
• Two affected parents can produce unaffected children, when both parents are⁵
• Horizontal pattern of inheritance indicates⁶
• All these are Autosomal Dominant Disorders except⁷.
• Skip of generation can occurs only when the trait is.⁸
• The normal pattern of autosomal dominant inheritance has exception(s)⁹

References

1. Color Atlas of Genetics  by Eberhard Passarge Fifth Edition (2017).Published by Thieme. Chapter: Formal Genetics. Topics:  MonogeneicInheritance. Page no. 114.  ↩︎
2. Color Atlas of Genetics  by Eberhard Passarge Fifth Edition (2017).Published by Thieme. Chapter: Formal Genetics. Topics:  Autosomal dominant Inheritance. Page no. 114.  ↩︎
3. Color Atlas of Genetics  by Eberhard Passarge Fifth Edition (2017).Published by Thieme. Chapter: Formal Genetics. Topics:  Autosomal recessive Inheritance. Page no. 114.  ↩︎
4. Genetics From Genes to Genome, By Michael L. Goldberg, Janice A. Fischer, Leroy Hood, & Leland H. Hartwell. 7^th Edition. (2021). Published by McGraw Hill LLC. Chapter no. 1 Mendel’s Principles of Heredity. Topics: A Vertical Pattern of Inheritance Indicates a Rare Dominant Trait. Page no. 16 ↩︎
5. Genetics From Genes to Genome, By Michael L. Goldberg, Janice A. Fischer, Leroy Hood, & Leland H. Hartwell. 7^th Edition. (2021). Published by McGraw Hill LLC. Chapter no. 1 Mendel’s Principles of Heredity. Topics: A Vertical Pattern of Inheritance Indicates a Rare Dominant Trait. Page no. 18 ↩︎
6. Genetics From Genes to Genome, By Michael L. Goldberg, Janice A. Fischer, Leroy Hood, & Leland H. Hartwell. 7^th Edition. (2021). Published by McGraw Hill LLC. Chapter no. 1 Mendel’s Principles of Heredity. Topics: A Horizontal Pattern of Inheritance Indicates a Rare Recessive Trait. Page no. 17 ↩︎
7. Genetics For Dummies®. By Tara Rodden Robinson, & Lisa Cushman Spock. 3^rd Edition. (2020). Published by John Wiley & Sons, IncC. PART 3 Genetics and Your Health. Chapter no. 15: Genetic Counseling, Risk Assessment, and Genetic Testing     Topics: Autosomal dominant traits and disorders &Autosomal recessive traits and disorders   Pages  no. 240-243 ↩︎
8. Genetics For Dummies®. By Tara Rodden Robinson, & Lisa Cushman Spock. 3^rd Edition. (2020). Published by John Wiley & Sons, IncC. PART 3 Genetics and Your Health. Chapter no. 15: Genetic Counseling, Risk Assessment, and Genetic Testing     Topics: Autosomal recessive traits and disorders   Pages  no. 242 ↩︎
9. Genetics For Dummies®. By Tara Rodden Robinson, & Lisa Cushman Spock. 3^rd Edition. (2020). Published by John Wiley & Sons, IncC. PART 3 Genetics and Your Health. Chapter no. 15: Genetic Counseling, Risk Assessment, and Genetic Testing     Topics: Autosomal dominant traits and disorders. Pages  no. 241 ↩︎